Romantic legacy in non-romantic times : two different-similar approaches to searching for self-identity

Wiele prac wskazuje na znaczący wpływ, jaki romantyczne dziedzictwo ma na twórczość współczesną. Dwudziestowieczni poeci i filozofowie żyjący w tych jakże nieromantycznych czasach mimo wszystko deklarowali swoje przywiązanie do romantycznych idei. Celem niniejszego artykułu jest skonfrontowanie dwóch podejść do tworzenia poezji, poszukiwania odrębności i pracy nad rozwojem intelektualnym i poetyckim. Robert Graves i Patrick Kavanagh to nie tylko poeci, ale i wielcy filozofowie poezji. Kavanagh czerpał z mistycyzmu, wyobraźni, z tego co nieodkryte i niepoznane. Graves podkreślał rolę wizji sennych, katartyczny charakter poezji i jej magiczne pochodzenie. Twórcy Ci reprezentują więc różne a zarazem i podobne podejście do poszukiwania tożsamości

Prevention and treatment of high altitude cerebral edema (HACE)

High altitude cerebral edema (HACE) is often a severe and potentially fatal manifestation of acute mountain sickness (AMS). It usually develops within the first 2 in individuals rapidly ascending at altitudes above 4000 m. The main cause of HACE is hypoxia, because of reduced oxygen level at high altitude.The aim of this study was to to assess the methods of prevention and treatment of high altitude cerebral edema (HACE).  Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. The first step was to find proper publications from the last 30 years. The second step was to carry out an overview of the found publications.Methods of prevention of acute mountain sickness are highly effective in high altitude cerebral edema prevention. Many studies estabilished the role of gradual ascent and staged ascent as well as administration of acetazolamide and dexamethasone in AMS prevention, and therefore in HACE prevention. Methods of treatments of acute mountain sickness are highly effective in high altitude cerebral edema treatment. Several researches proved the role of descent, administration of acetazolamide and dexamethasone, oxygen therapy as well as use of portable hyperbaric chamber in AMS treatment, and therefore in HACE treatment. However HACE treatment requires greater descent and larger doses of dexamethasone. Also duration of recovery is longer

Prevention and treatment of high altitude pulmonary edema (HAPE)

High-altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic pulmonary edema, that develops within the first 2–5 days in rapidly ascending individuals at altitudes above 2,500-3,000 m. The clinical features are cyanosis, tachypnoea,tachycardia and elevated body temperature generally not exceeding 38.5 °C. It is often severe and potentially fatal manifestation of acute mountain sickness (AMS).The aim of this study was to assess the methods of prevention and treatment of high altitude pulmonary edema (HAPE). Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. The first step was to find proper publications from the last 30 years .The second step was to carry out an overview of the found publications.Gradual ascent and staged ascent are the most effective methods of prevention of HAPE Pharmacologic prophylaxis with nifedipine should only be considered for individuals with a history of HAPE.  Before initiating treatment of HAPE differential diagnosis should be done. Descent shoud be initaited and oxygen therapy shoud be started when HAPE is suspected or diagnosed. If these methods are unavailable, nifedipine or Gamow bag can be used

Treatment of traveler's diarrhea - clinical review

Travelers’ diarrhea is defined as the passage of three or more unformed stools per 24 hours plus at least one additional symptom such as nausea, vomiting, abdominal cramps, fever, blood/mucus in the stools, or fecal urgency that develop while abroad or within 14 days of returning from any resource-limited destinations.The aim of this study was to show the methods of treatment of traveler's diarrhea. Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. In order to find the proper publications, the search has been conducted with the use of a combination of key words like: '' traveler's diarrhea,'', ''travel'', ''diarrhea'', ''antibiotic". The first step was to find proper publications from the last 30 years .The second step was to carry out an overview of the found publications.Major goals of treatment of the traveler's diarrhea are: to maintain optimal hydration level, to reduce the severity and duration of diarrhea and to eradicate pathogenic agents responsible for causing this disease. The choice of the best possible method of tretament of traveler's diarrhea depends on the patient's general condition, his medical history, severity and duration of diarrhea and the pathogenic agent that causes this disease

The non-orthogonal Serret–Frenet parametrization applied to the path following problem of a manipulator with partially known dynamics

In this paper an application of the Serret–Frenet parametrization of a curve to the path following task is presented. This curvilinear parametrization method is used to obtain a control object description relative to the desired curve defined in the three-dimensional space. In order to derive proper equations, the innovative approach of the non-orthogonal projection of a control object on the given path is investigated. The non-orthogonal projection allows to design a global control algorithm. The proposed solution results in a cascade structure of the control system. Thus, the backstepping integrator algorithm was applied to create a control law. Due to the partial knowledge of control object dynamic parameters, an adaptive algorithm is taken into account. Theoretical considerations are confirmed with simulation study. Conducted simulations illustrated following paths at different levels of complexity by a holonomic non-redundant manipulator with a fixed base

The Assessment of Fear of COVID-19 among the Elderly Population: A Cross-Sectional Study

The prevailing COVID-19 pandemic has dramatically affected the mental health and well-being of individuals. This cross-sectional study aimed to assess the perceived fear of COVID-19 among older adults in Poland and identify subpopulations with the highest risk of potential mental health disorders. The study was conducted in November–December 2020 on 500 people aged ≥60 years (mean M = 67.9, standard deviation SD = 4.2). In order to collect information on participants’ characteristics and COVID-19-related information, they were asked to complete a questionnaire based on recorded telephone calls. Perceived fear of COVID-19 was measured using our generated and validated seven-item tool: “Scale of fear of COVID-19 infection”, which ranged from 7 to 35. Multiple linear regression was performed to identify factors associated with the perceived fear of COVID-19. Our results showed that the highest level of fear of COVID-19 infection was observed among women (p = 0.025) and patients taking anticoagulants (p = 0.004). Moreover, older adults with higher anxiety levels were more likely to be fearful of COVID-19 (according to the GAS-10 scale; p < 0.001). These findings may help policy makers and healthcare workers to adapt and implement better mental health strategies to help the elderly fight fear and anxiety during the prevailing pandemic

Effect of heme oxygenase-1 on melanoma development in mice : role of tumor-infiltrating immune cells

Objective: Heme oxygenase-1 (HO-1) is a cytoprotective, proangiogenic and anti-inflammatory enzyme that is often upregulated in tumors. Overexpression of HO-1 in melanoma cells leads to enhanced tumor growth, augmented angiogenesis and resistance to anticancer treatment. The effect of HO-1 in host cells on tumor development is, however, hardly known. Methods and results: To clarify the effect of HO-1 expression in host cells on melanoma progression, C57BL/6xFvB mice of different HO-1 genotypes, HO-1+/+, HO-1+/&minus;, and HO-1&minus;/&minus;, were injected with the syngeneic wild-type murine melanoma B16(F10) cell line. Lack of HO-1 in host cells did not significantly influence the host survival. Nevertheless, in comparison to the wild-type counterparts, the HO-1+/&minus; and HO-1&minus;/&minus; males formed bigger tumors, and more numerous lung nodules; in addition, more of them had liver and spleen micrometastases. Females of all genotypes developed at least 10 times smaller tumors than males. Of importance, the growth of primary and secondary tumors was completely blocked in HO-1+/+ females. This was related to the increased infiltration of leukocytes (mainly lymphocytes T) in primary tumors. Conclusions: Although HO-1 overexpression in melanoma cells can enhance tumor progression in mice, its presence in host cells, including immune cells, can reduce growth and metastasis of melanoma

Radioimmunotherapy in follicular lymphomas, a retrospective analysis of the Polish Lymphoma Research Group's (PLRG) experience

BACKGROUND: Ibritumomab is an 90Yttrium (90Y) labelled radioimmunoconjugate registered to treat follicular lymphoma relapsing or refractory after Rituximab therapy. Combining the specificity of anti CD20 monoclonal antibodies with the efficacy of radiotherapy, it is particularly effective in patients with advanced stages of disease with generalized lymphadenopathy. MATERIAL AND METHODS: Twenty-one patients with follicular lymphoma, after failing 2-5 lines of previous treatment, were subjected to radioimmunotherapy in three Polish Lymphoma Research Group (PLRG) centres. Ibritumomab infusion was followed by 2 doses of Rituximab (250 mg/m2 at day -7 and 0) to enhance its biodistribution. Radioimmunoconjugate was prepared in the Nuclear Medicine Departments of participating centres based on patient weight and full blood count results (14.8 MBq/kg, max 1200 MBq, reduced to 11.1 MBq/kg in cases with blood platelet 100 000-150 000 or leukocytes 1500-2000). 14.8 MBq/kg (0.4 mCi/kg) 100 thousand to 149 thousand/mm3 platelets 11.1 MBq/kg (0.3 mCi/kg) RESULTS: The primary endpoint of the study was the assessment of response rate and haematological toxicity. Objective responses were observed in all patients, with 10 partial and 12 complete regressions. Cytopenia, starting 3-4 weeks after radioimmunotherapy, reflected haematological toxicity - the only important side effect. Thrombocytopenia was more pronounced, with platelet counts of < 50,000/ul in every second patient. One patient developed myelodysplastic syndrome 21 months after the procedure. After the medium time of follow up over 2 years, 2 patients died. Median progression free survival (secondary study endpoint) was 15 months. CONCLUSIONS: Ibritumomab radioimmunotherapy is an efficient method of palliation treatment of heavily pre-treated follicular lymphoma patients, failing numerous previous treatment lines. Earlier application increases the number of complete responses and prolongs progression free survival